Coleus Forskohlii (Sfera Bio Nutrition)

Description

60 capsules
Ingredients:
One vegetarian capsule provides:
Forslean® Coleus Forskohlii Extract (10%)   100mg
Coleus Forskohlii Powder                               300mg
Other ingredients: Cellulose vegi-capsule, vegetarian magnesium stearate

Directions to use: Take 1 to 3 capsules daily with water at mealtimes or as directed by your healthcare practitioner.

What is Forslean®:
A standardize powdered extract from the roots of the coleus forskohlii plant, cultivated in Southern India, which is a patented, clinically-examined weight management product.

How does Forslean® assist with weight loss:
Forskohlin stimulates adenylate cyclase and cyclic AMP Levels.
An increase in cyclic AMP leads to the activation of protein kinase. Protein kinase has been shown to activate the hormone sensitive lipase which is involved in the breakdown of triglycerides, known as building blocks of fatty tissue. Adenylate cyclise is an enzyme involved in the production of cyclic Adenosine Monosposphate (cAMP), from high energy molecule, ATP (Adenosine triphosphate).
The other factor relevant to the weight loss mechanism of forskohlin involves its thyroid stimulating action, comparable in strength to thyrotropin or TSH. The thyroid stimulating action of forskohlin may also contribute to the increase in the metabolic rate and thermo genesis.
Forskohlin may also be involved in regulating insulin secretion. Insulin, although well recognised for its metabolism of carbohydrates, is also involved in the metabolism of fats and proteins that are major contributors to body composition.

More health benefits of Forskohlin:
Coleus is the most potent herbal antihistamine.
Asthma: Forskohlin stabilizes the mast cells in the lining of the lungs to keep them from releasing massive amounts of histamine in response to irritation. This prevents asthma attacks in response to exposure to dust particles, smoke and allergens.
Eczema: Forskohlin reactivates beta-agonists, chemicals that stop the release of histamines that causes skin inflammation in eczema. Eczema, hay fever, psoriasis and asthma are conditions marked by low cAMP and high platelet activating factor (PAF) levels.
High blood pressure: Forskohlin relaxes the smooth muscles surrounding the arteries to lower blood pressure, slowing the pulse and strengthening the heart beat. Very similar action to prescription calcium channel blockers. It may benefit congestive heart failure and enhance the heart function.
Glaucoma: Reduces intraocular pressure (Berstein et al 1984)

Interactions with herbs and other dietary supplements:

1. Theoretically, concomitant use of forskohlin and cardio active herbs could potentiate the cardiac effects and adverse reactions. Some cardio active herbs include: calamus, cereus, cola, coltsfoot, devil’s claw, European mistletoe, fenugreek, ginger, Panax ginseng, white horehound, mate, parsley, quassia, shepherd’s purse, wild carrot, digitalis and lily-of-the –valley roots.
2. Theoretically, concomitant use of forskohlin with herbs that affect platelet aggregation could potentially increase the risk of bruising and bleeding. Some of these herbs include: angelica, arnica, asafoetida, boldo, capsicum, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, horseradish, licorice, meadosweat, prickly ash, onion, papain, passionflower, red clover, turmeric, wild carrot, willow and others.

Interactions with drugs:

1. Forskohlin counteracts the effect of oral contraceptives used to treat ovarian cysts.
2. Forskohlin increases levels of cAMP, and laboratory studies indicate that intermittent burst of cAMP production can cause demineralising of bone. If you have osteoporosis, avoid forskohlin.
3. Because it relaxes and dilates the blood vessels, forskohlin reduces the load on the heart. People taking warfarin and other blood-thinning medications should avoid Coleus or forskohlin.
4. Using forskohlin with calcium channel blockers might cause additive coronary vasodilatory effects.
5. Using forskohlin with nitrates might cause additive vasodilatory effects.
   

Interactions with Diseases or Conditions

1. Theoretically forskohlin might increase the risk of bleeding in bleeding disorders
2. There is some concern that forskohlin might interfere with treatment of cardiovascular disease.