MSM Combo, 120 capsules (Salvita)

120 capsules
Ingredients:
Each capsule contains:
OptiMSM (Methylsulphonylmethane)    500mg
Boron ACC 5%                                                 10mg
Molybdenum AAC 0.2%                                12mg       
Magnesium malate 16%                                50mg                                                              
Calcium ascorbate                                        100mg                                      
Vitamin A (Retinyl Acetate 500)                   2mg
Vitamin B1 (Thiamine HCL)                        20mg
Vitamain B2 (Riboflavin)                             10mg
Other ingredients: HPMC vegetable capsule

• No colourant
• No fillers
• No gluten
• No preservatives

Directions to use: 
Adults & children over 12 years old: Take 3 capsules as a once-off or divided dosage. Start with 1 capsule daily and slowly increase the dosage. Best to take morning and afternoon.

Did you know?
Methylsulfonylmethane (MSM), a sulfur-donor, will increase intracellular inorganic sulfate levels and contribute to the sulfation of glycosaminoglycans in the glycocalyx, therefore exhibiting antimicrobial and immune modulating properties 1-3. A well-sulfated, intact epithelial and endothelial glycocalyx, contribute to pathogen evasion and barrier functions, the regulation of inflammation, vascular permeability and tone, coagulation, the mediation of shear stress 4, 5, lipid metabolism 6, 7, immune modulation and leukocyte adhesion8-10, as well as protection against oxidative stress4. Therefore, any changes in the degree of sulfation due to reduced availability of inorganic sulfate, are associated with a wide range of pathophysiological consequences, such as capillary leak syndrome and consequent oedema formation11, accelerated inflammation, hypercoagulation, platelet hyperaggregation, and loss of vascular responsiveness 5, 6.
Furthermore, as a source of organic sulfur, MSM will increase the synthesis of other sulfur amino acids and glutathione 12, apart from inorganic sulfate 2, 3. It was shown that MSM attenuated paraquat-induced pulmonary and hepatic injury in mice, confirmed by the reduction of inflammatory markers and the increase in superoxide dismutase, glutathione, and catalase levels in lung and liver tissues12. Several research studies demonstrated that MSM inhibits lipopolysaccharide-induced release of oxidative stress biomarkers, such as nitric oxide and prostaglandin E2 in macrophages, through downregulation of NF-κB signaling 13, 14. It has been established that MSM potentially inhibits the translocation of the p65 subunit of NF-κB to the nucleus, thereby minimising downstream events associated with local and systemic inflammation 15-17.  Indeed, it has been demonstrated that supplementation with MSM will minimise the expression of many pro-inflammatory cytokines 12, 15, 17.  MSM attenuated experimental colitis by reducing IL-1b levels and protected against hepatic liver injury by decreasing TNFα and IL-6 levels 12, 18. In another study, MSM significantly mitigated lung and pancreatic histopathological changes, decreased serum amylase and myeloperoxidase activity, and inhibited caerulein-induced IL-1b expression 16. The availability of inorganic sulfate for glycosaminoglycan sulfation has been associated with the development of many inflammatory diseases19, such as atherosclerosis, stroke, sepsis, diabetes mellitus and related renal diseases, cardiovascular diseases, hypertension, obesity, pulmonary diseases, and various cancers4, 8, 20-27. MSM suppresses hepatic tumour development through activation of apoptosis and breast cancer growth by down-regulating STAT3 and STAT5b pathways 14, 28.
MSM is entirely safe and effective, taken at daily dosages of up to 4 g to prevent and treat inflammatory diseases1.

Disclaimer: This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.